3-[4-METHYL-2-[(2-OXO-1H-INDOL-3-YLIDENE)METHYL]-1H-PYRROL-3-YL]PROPANOIC ACID
SU 5402
CAS: 215543-92-3
Molecular Formula: C17H16N2O3
3-[4-METHYL-2-[(2-OXO-1H-INDOL-3-YLIDENE)METHYL]-1H-PYRROL-3-YL]PROPANOIC ACID - Names and Identifiers
3-[4-METHYL-2-[(2-OXO-1H-INDOL-3-YLIDENE)METHYL]-1H-PYRROL-3-YL]PROPANOIC ACID - Physico-chemical Properties
| Molecular Formula | C17H16N2O3 |
| Molar Mass | 296.32 |
| Density | 1.363±0.06 g/cm3(Predicted) |
| Melting Point | >222°C (dec.) |
| Boling Point | 592.6±50.0 °C(Predicted) |
| Solubility | DMSO: soluble10mg/mL (clear solution) |
| Appearance | powder |
| Color | light orange to dark orange |
| pKa | 4.60±0.10(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| In vitro study | SU5402 inhibited VEGF-,FGF-, and PDGF-dependent cell proliferation with an IC50 of 0.05 μm, 2.80 μm, and 28.4 μm, respectively. In HUVECs, SU5416 selectively inhibited VEGF-driven mitogenesis in a dose-dependent manner with an IC50 of 0.04 μm. In Nasopharyngeal Epithelial Cells, SU5402 attenuates lmp1-mediated aerobic glycolysis, cell transformation, cell migration, and invasion. In mouse C3H10T1/2 cells, SU 5402 reduced the effect of FGF23 on cell differentiation. |
| In vivo study | In mice, SU5416 (25 mg/kg, I. p.) inhibited the subcutaneous growth of a panel of cancer cell lines by inhibiting the angiogenic processes associated with tumor growth. |
3-[4-METHYL-2-[(2-OXO-1H-INDOL-3-YLIDENE)METHYL]-1H-PYRROL-3-YL]PROPANOIC ACID - Risk and Safety
| WGK Germany | 3 |
3-[4-METHYL-2-[(2-OXO-1H-INDOL-3-YLIDENE)METHYL]-1H-PYRROL-3-YL]PROPANOIC ACID - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.375 ml | 16.874 ml | 33.747 ml |
| 5 mM | 0.675 ml | 3.375 ml | 6.749 ml |
| 10 mM | 0.337 ml | 1.687 ml | 3.375 ml |
| 5 mM | 0.067 ml | 0.337 ml | 0.675 ml |
Last Update：2024-01-02 23:10:35
3-[4-METHYL-2-[(2-OXO-1H-INDOL-3-YLIDENE)METHYL]-1H-PYRROL-3-YL]PROPANOIC ACID - Reference Information
| biological activity | SU5402 is an effective multi-target receptor kinase inhibitor with IC50 for VEGFR2,FGFR1, and PDGF-Rβ of 20 nM,30 nM, and 510 nM respectively. |
| target | TargetValue VEGFR2 (Cell-Free Assay) 20 nM FGFR1 (Cell-Free Assay) 30 nM PDGFRβ (Cell-Free Assay) 510 nM |
| Target | Value |
| VEGFR2 (Cell-free assay) | 20 nM |
| FGFR1 (Cell-free assay) | 30 nM |
| PDGFRβ (Cell-free assay) | 510 nM |
| in vitro study | SU5402 inhibited VEGF-,FGF-,PDGF-dependent cell proliferation with IC50 of 0.05 μM,2.80 μM and 28.4 μM respectively. In HUVECs, SU5416 selectively inhibits VEGF-driven mitosis in a metered-dependent manner with an IC50 of 0.04 μM. In nasopharyngeal epithelial cells, SU5402 attenuates LMP1-mediated aerobic glycolysis, cell transformation, cell migration, and invasion. In mouse C3H10T1/2 cells, SU 5402 reduce the effect of FGF23 on cell differentiation. |
| in vivo studies | in mice, SU5416 (25 mg/kg, I. p.) inhibits the subcutaneous growth of a group of cancer cell lines by inhibiting the angiogenesis process associated with tumor growth. |
Last Update：2024-04-09 21:54:55
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Featured ProductsSpot supply
Product Name: SU5402 Visit Supplier Webpage Request for quotationCAS: 215543-92-3
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple SpecificationsSpot supply
Product Name: SU 5402 Visit Supplier Webpage Request for quotationCAS: 215543-92-3
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: SU 5402 Visit Supplier Webpage Request for quotationCAS: 215543-92-3
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: SU 5402 Visit Supplier Webpage Request for quotationCAS: 215543-92-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
3-[4-METHYL-2-[(2-OXO-1H-INDOL-3-YLIDENE)METHYL]-1H-PYRROL-3-YL]PROPANOIC ACID
O-Methyl O-(4-methyl-2-nitrophenyl) (1-methylethyl)phosphoramidothioate
(S)-2-(((((9H-芴-9-基)甲氧基)羰基)氨基)-5-((叔丁氧基羰基)氨基)-2-甲基戊酸
N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE
3-PYRROLIDINEPROPANAMIDE, 伪-AMINO-2-OXO-, HYDROCHLORIDE
(S)-2-乙酰氨基-4-((叔丁氧羰基)氨基)丁酸
N-{4-[(4-METHOXYANILINO)CARBONYL]PHENYL}-2-OXO-1-OXASPIRO[4.5]DECANE-4-CARBOXAMIDE
N-[2-(P-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE
2-氯-3-甲基吡啶-5-硼酸 (含不同量的酸酐)
4-[[[(3-CHLORO-4-ETHOXYBENZOYL)AMINO]THIOXOMETHYL]AMINO]-BENZOIC ACID
O-Methyl O-(4-methyl-2-nitrophenyl) (1-methylethyl)phosphoramidothioate
(S)-2-(((((9H-芴-9-基)甲氧基)羰基)氨基)-5-((叔丁氧基羰基)氨基)-2-甲基戊酸
N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE
3-PYRROLIDINEPROPANAMIDE, 伪-AMINO-2-OXO-, HYDROCHLORIDE
(S)-2-乙酰氨基-4-((叔丁氧羰基)氨基)丁酸
N-{4-[(4-METHOXYANILINO)CARBONYL]PHENYL}-2-OXO-1-OXASPIRO[4.5]DECANE-4-CARBOXAMIDE
N-[2-(P-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE
2-氯-3-甲基吡啶-5-硼酸 (含不同量的酸酐)
4-[[[(3-CHLORO-4-ETHOXYBENZOYL)AMINO]THIOXOMETHYL]AMINO]-BENZOIC ACID